A partial least-squares statistical model was prepared to describe the contamination of produced water by soluble organic compounds. The model incorporated predictor variables used in earlier characterization studies: pH, temperature, pressure, salinity, water-to-oil ratio, and origin of the crude. Response variables included total extractable material and concentrations of aliphatic, aromatic, and polar organic molecules. The model was used to predict the uptake of water-soluble organics under a variety of conditions. The model will be applied to the prediction of hydrocarbon contamination of water produced in offshore drilling.