The dynamic behavior of ozonation with pollutant in a rotating packed bed is studied for the model establishment. o-Cresol is chosen as the model pollutant. The concentrations of the residual o-cresol, effluent dissolved oxygen, and off-gas ozone at various times are measured simultaneously. The validity of the model is demonstrated by comparing the predicted results with the experimental data. Furthermore, the assumption of complete as well as partial wetting of packing is examined by comparison of the prediction with the experimental data. The patterns of the concentration profiles in the packed bed vary with the ozonation time in the transient state until reaching the steady state. It usually needs about 2 hydraulic retention times to reach steady state under the conditions of this study. The effects of dimensionless system parameters such as Damkohler and Stanton numbers on the performance of the ozonation process are also investigated.