Journal of Bioscience and Bioengineering, Vol.96, No.4, 344-348, 2003
Microbial glycosylation and acetylation of brefeldin A
The brefeldin A (BFA) derivatives 4-O-acetyl BITA, 7-O-acetyl BFA, and 4-O-D-glucosyl BFA were found by the microbial conversion of BFA. 4-O-D-Glucosyl BFA is a novel compound produced by the conversion of BFA with Streptomyces sp. Q53834. The cytotoxicity and antifungal activity of all of the compounds were markedly less than those of BFA.