Journal of the Korean Industrial and Engineering Chemistry, Vol.16, No.1, 15-20, February, 2005
경피 흡수와 연구동향
Transdermal Drug Delivery System
E-mail:
초록
최근 약물전달시스템에 관심이 높아지면서 질병 치료를 목적으로 치료용 약물들이 많이 개발되기 시작하였으며, 이 중 경피흡수제제는 여러 가지 이점으로 인하여 지속적으로 연구를 진행하고 있는 흥미로운 분야이다. 본 고에서는 이러한 경피흡수의 원리 및 흡수를 촉진하는 물질들에 대하여 서술하였으며, 이를 발전시키기 위한 in vitro 및 in vivo 연구에 대하여 논하였다.
Many scientists have been interested in drug delivery system (DDS) which improves medical treatment for curing a disease. Transdermal drug delivery (TDD) that is one of the DDS offers several advantages over the traditional methods. For this reason, the study of TDD has been investigated in various field. In this paper, principle of transdermal delivery and penetration enhancers into the skin including in vitro and in vivo data have been studied.
- Ansel HC, Popovich NG, Allen LV, Pharmaceutical Dosage Forms and Drug Delivery Systems, 357, Williams and Wilkins, Malvern (1995)
- Williams AC, Barry BW, Critical Reviews in Therapeutic Drug Carrier Systems, 9, 305 (1992)
- Moser K, Kriwet K, Naik A, Kalia YN, Guy RH, Eur. J. Pharm. Biopharm. Biopharm., 52, 103 (2001)
- Wood EJ, Bladon PT, The Human Skin: Studies in Biology Series, 164, Edward Arnold, London (1985)
- Marks RM, Barton SP, Edwards C, The physical Nature of the Skin, MTR Press Ltd., Lancaster (1988)
- Bouwstra JA, Honeywell-Nguyen PL, Adv. Drug Deliv. Rev., 54, S41 (2002)
- Wilkes GL, Brown IA, Widnauer RH, Critical Review of Bioengineering, 1, 453 (1973)
- Lampe MA, Burligame AL, Whitney J, Williams ML, Brown BE, Roitman E, Elias PM, J. Lipid Res., 24, 120 (1983)
- Elias PM, Int. J. Dermatol., 20, 1 (1981)
- Wertz PW, Madison KC, Downing DT, Inbestigative Dermatology, 92, 109 (1989)
- Elias PM, Friend DS, J. Cell Biol., 65, 180 (1975)
- Grayson S, Elias PM, J. Invest. Dermatol., 78, 128 (1982)
- Williams ML, Elias PM, Crit. Rev. Ther. Drug Carr. Syst., 3, 95 (1987)
- Knutson K, Potts RO, Guzek DB, Golden GM, McKie JE, Lambert WJ, Higuchi WI, Macro- and Molecular Physical-Chemical Considerations in Understanding Drug Transport in the Stratum Corneum, In Advances in Drug Delivery Systems, eds. J. M. Anderson, and S. W. Kimeds, 1, 67, Elsevier, Amsterdam (1986)
- Potts RL, Physical Characterization of the Stratum Corneum: the Relationship of Mechanical and Barrier Properties to Lipid and Protein Structure, Transdermal Drug Delivery; Developmental Issues and Research Initiatives, eds. J. Hadgraft, and R. H. Guy, Ch. 2, Marcel Dekker, New York (1989)
- White SH, Mirejovsky D, King GI, Biochemistry, 27, 3725 (1988)
- Barry BW, The LPP Theory of Skin Penetration, in In Vitro Percutaneous Absorption: Principles, Fundamentals and Applications, eds. R. L. Bronaugh, and H. I. Maibach, 165, CRC Pres. Boca Raton (1991)
- Bos JD, Meinardi MM, Exp. Dermatol., 9, 165 (2000)
- Wertz PW, Downing DT, Transdermal Drug Delivery: Developmental Issues and Research Initiatives, eds. J. Hadgraft, and R. H. Guy, 1, Marcel Dekker, New York, Basel, Hong Kong (1989)
- Guy RH, Pharm. Res., 13, 1765 (1996)
- Karande P, Jain A, Mitragotri S, Nat. Biotechnol., 22, 192 (2004)
- Guy RH, Kalia YN, Delgado-Charro MB, Merino V, Lopez A, Marro D, J. Control. Release, 64, 129 (2000)
- Mitragotri S, Blankschtein D, Langer R, Science, 269(5225), 850 (1995)
- Finnin BC, Morgan TM, J. Pharm. Sci., 88, 955 (1999)
- French E, Potton C, Walters K, Pharmaceutical Skin Penetration Enhancement, eds. K. Walters, and J. Hadgraft, 113, Marcel Dekker, New York (1993)
- Kanikkannan N, Kanimalla K, Lamba SS, Singh M, Curr. Med. Chem., 7, 593 (2000)
- Lashmar UT, Hdgraft J, Thomas N, J. Pharm. Pharmacol., 41, 118 (1989)
- Suhonen M, Bouwstra J, Urtti A, J. Control. Release, 59, 149 (1999)
- Mitragotri S, Pharm. Res., 18, 1022 (2001)
- Robinson MK, Perkins MA, American J. Contact Dermatitis, 13, 19 (2002)
- Williams AC, Barry BW, Adv. Drug Deliv. Rev., 56, 603 (2004)
- Kligman AM, JAMA, 193, 796 (1965)
- Southwell D, Barry BW, J. Invest. Dermatol., 80, 507 (1983)
- Park ES, Chang SJ, Rhee YS, Chi SC, Drug Dev. Ind. Pharm., 27, 975 (2001)
- Aboofazeli R, Zia H, Needham TE, Drug Deliv., 9, 239 (2002)
- Santoyo S, Ygartua P, Eur. J. Pharm. Biopharm., 50, 245 (2000)
- Goodman M, Barry BW, Int. J. Pharm., 57, 29 (1989)
- Berner B, Mazzenga GC, Otte JH, Steffens RJ, Juang RH, Ebert CD, J. Pharm. Sci., 78, 402 (1989)
- Kurihara-Bergstrom T, Knutson K, DeNoble LJ, Goates CY, Pharmacol. Res., 7, 762 (1990)
- Tupker RA, Pinnagoda J, Nater JP, Acta Derm. -Venereol., 70, 1 (1900)
- Franz TJ, J. Invest. Dermatol., 64, 190 (1975)
- Maibach HI, Animal Models in Dermatology, Churchill- Livingstone, Edinburgh (1975)
- Mali JHW, Current Problems in Dermatology, 7, Karger, Basel (1978)
- Bronaugh RL, Stewart RF, Congdon ER, Giles AL, Applied Pharmacology, 62, 481 (1982)
- Barry BW, Dermatological Formulations: Percutaneous Absorption. Drugs and the Pharmaceutical Sciences, 18, Marcel Dekker, New York (1983)
- Bronaugh RL, Maibch HI, J. Invest. Dermatol., 84, 180 (1985)
- Bronaugh RL, Maibach HI, Percutaneous Penetration, Marcel Dekker, London (1985)
- Friend DR, J. Control. Release, 18, 235 (1992)
- Bartek MJ, LaBudde JA, Maibach HI, J. Invest. Dermatol., 58, 114 (1972)
- Marzulli FN, Maibach HI, Relevance of Animal Models: the Hexachlorophene Story, ed. H. I. Maibach, Animal Models in Dermatology, Churchill-Livingstone, Edinburgh (1975)
- Roberts ME, Mueller KR, Pharm. Res., 7, 673 (1990)
- Harada K, Murakami T, Kawasaki E, Hagashi Y, Yamamoto S, Yata N, J. Pharm. Pharmacol., 45, 414 (1993)
- Pongjanyakul T, Prakongpan S, Panomsuk S, Puttipipathkhachorn S, Priprem A, J. Pharm. Pharmacol., 54, 1345 (2002)
- Moss GP, Dearden JC, Patel H, Cronin MT, Toxicol. Vitro, 16, 299 (2002)
- Reinfenrath WG, Chellquist EM, Shipwash EA, Jederberg WW, Krueger GG, Br. J. Dermatol., 111, 123 (1984)