화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Journal of Industrial and Engineering Chemistry, Vol.10, No.7, 1146-1155, December, 2004
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Mesoporous Materials with Spherical Morphology: Synthesis and Bioapplication
Haifeng Yang, Yan Yan, and Dongyuan Zhao†
  • Department of Chemistry, Laboratory of Molecular Catalysis and Innovative Materials, Fudan University, Shanghai 200433, China
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Morphology control is one of the most interesting issues in the research field of mesoporous materials. It plays a very important role in understanding the basic synthesis mechanism of the kind of materials. Moreover, the future applications of mesoporous materials are strongly depended on their tunable macroscopical morphologies. Mesoporous materials with spherical morphology are quite attractive due to the potential applications in macromolecular separations, drug deliveries, catalysis supports and template agents for photonic crystals. Researches on synthesis and properties of the materials have been carried out for nearly ten years. In this article, several synthetic methods for both siliceous and non-siliceous mesoporous spheres are reviewed, including solution self-assembly, aerosol spraying and hard templating route. The mechanism of self-assembly in solution system is provided and the rational controls for synthetic conditions are specifically discussed. With the viewpoint of applications, some examples are given in the aspects of bioseparations, drug delivery and catalysis. A short summary has listed some overviews for future developments.
Keywords:mesoporous materials;morphological control;spheres;hard template;chromatography;drug delivery
  1. Kresge CT, Leonowicz ME, Roth WJ, Vartuli JC, Beck JS, Nature, 359, 710 (1992)
  2. Beck JS, Vartuli JC, Roth WJ, Leonowicz ME, Kresge CT, Schmitt KD, Chu CTW, Olsen DH, Sheppard EW, McCullen SB, Higgins JB, Schlenker JL, J. Am. Chem. Soc., 114, 10834 (1992)
  3. Ying JY, Mehnert PC, Wong MS, Angew. Chem.-Int. Edit., 38, 56 (1999)
  4. Huo QS, Margolese DL, Ciesla U, Feng PY, Gier TE, Sieger P, Leon R, Petroff PM, Schuth F, Stucky GD, Nature, 378, 317 (1994)
  5. Kim SS, Zhang WZ, Pinnavaia TJ, Science, 282(5392), 1302 (1998)
  6. Inagaki S, Guan S, Osuna T, Terasaki O, Nature, 416, 304 (2002)
  7. Zhao DY, Feng JL, Huo QS, Melosh N, Fredrickson GH, Chmelka BF, Stucky GD, Science, 279(5350), 548 (1998)
  8. Che S, Garcia-Bennett AE, Yokoi T, Sakamoto K, Kunieda H, Terasaki O, Tatsumi T, Nat. Mater., 2, 801 (2003)
  9. Che S, Liu Z, Ohsuna T, Sakamoto K, Terasaki O, Tatsumi T, Nature, 429, 281 (2004)
  10. Zhao DY, Yang PD, Huo QS, Chmelka BF, Stucky GD, Curr. opin. Solid State Mat. Sci., 3, 111 (1998)
  11. Zhao D, Yang P, Melosh N, Feng J, Chmelka BF, Stucky GD, Adv. Mater., 10, 1380 (1998)
  12. Zhao D, Yang P, Margolese DI, Chmelka BF, Stucky GD, Chem. Commun., 2499 (1998)
  13. Miyata H, Noma T, Watanabe M, Kuroda K, Chem. Mater., 14, 766 (2002)
  14. Kim Y, Yang S, Adv. Mater., 14, 1078 (2002)
  15. Yu CZ, Tian BZ, Fan J, Stucky GD, Zhao DY, J. Am. Chem. Soc., 124(17), 4556 (2002)
  16. Yang P, Zhao D, Chmelka BF, Stucky GD, Chem. Mater., 10, 2033 (1998)
  17. Marlow F, Spliethoff B, Tesche B, Adv. Mater., 12, 961 (2000)
  18. Bagshaw SA, Prouzet E, Pinnavaia TJ, Science, 269(5228), 1242 (1995)
  19. Templin M, Franck A, Duchesne A, Leist H, Zhang YM, Ulrich R, Schadler V, Wiesner U, Science, 278(5344), 1795 (1997)
  20. Gltner CG, Henke S, Weissenberger MC, Antonietti M, Angew. Chem.-Int. Edit., 37, 613 (1998)
  21. Melosh NA, Lipic P, Bates FS, Wudl F, Stucky GD, Fredrickson GH, Chmelka BF, Macromolecules, 32(13), 4332 (1999)
  22. Melosh NA, Davidson P, Chmelka BF, J. Am. Chem. Soc., 122(5), 823 (2000)
  23. Feng PY, Bu XH, Stucky GD, Pine DJ, J. Am. Chem. Soc., 122(5), 994 (2000)
  24. Melosh NA, Davidson P, Feng P, J. Am. Chem. Soc., 123, 1240 (2000)
  25. Stein A, Adv. Mater., 15, 763 (2003)
  26. Nooney RI, Thirunavukkarasu D, Chen Y, Josephs R, Ostafin AE, Chem. Mater., 14, 4721 (2002)
  27. Rao GVR, Lopez GP, Bravo J, Pham H, Datye AK, Xu H, Ward TL, Adv. Mater., 14, 1301 (2002)
  28. Valtchev V, Chem. Mater., 14, 956 (2002)
  29. Huo Q, Zhao D, Feng JL, Weston K, Buratto SK, Stucky GD, Schacht S, Schuth F, Adv. Mater., 9, 974 (1997)
  30. Israelachvili JN, Colloids Surf. A: Physicochem. Eng. Asp., 91, 1 (1994)
  31. Lee JS, Joo SH, Ryoo R, J. Am. Chem. Soc., 124(7), 1156 (2002)
  32. Ryoo R, Joo SH, Kim JM, J. Phys. Chem. B, 103(35), 7435 (1999)
  33. Qi L, Ma J, Cheng H, Zhao Z, Chem. Mater., 10, 1623 (1998)
  34. Zhao D, Sun J, Li Q, Stucky GD, Chem. Mater., 12, 275 (2000)
  35. Yu C, Fan J, Zhao D, Acta Chim. Sin., 60, 1357 (2002)
  36. Yang H, Coombs N, Sokolov I, Ozin GA, J. Mater. Chem., 7, 1285 (1997)
  37. Yang H, Coombs N, Ozin GA, Nature, 386(6626), 692 (1997)
  38. Oliver S, Kuperman A, Coombs N, Lough A, Ozin GA, Nature, 378(6552), 47 (1995)
  39. Schacht S, Huo Q, Voigtmartin IG, Stucky GD, Schuth F, Science, 273(5276), 768 (1996)
  40. Grun M, Lauer I, Unger KK, Adv. Mater., 9, 254 (1997)
  41. Stober W, Bohn EJ, J. Colloid Interface Sci., 26 (1968)
  42. Luo Q, Li L, Xue Z, Zhao D, Chem. Res. Chin. Univ., 17, 143 (2001)
  43. Yu C, Tian B, Fan J, Stucky GD, Zhao D, Chem. Lett., 62 (2002)
  44. Yang S, Coombs N, Ozin GA, Adv. Mater., 12, 1940 (2000)
  45. Cai Q, Luo Z, Pang W, Fan Y, Chen X, Cui F, Chem. Mater., 13, 258 (2001)
  46. Huo Q, Margolese DI, Ciesla U, Demuth DG, Feng P, Gier T, Sieger P, Firouzi A, Chmelka BF, Schuth F, Stucky GD, Chem. Mater., 6, 1176 (1994)
  47. Frasch J, Lebeau B, Soulard M, Patarin J, Zana R, Langmuir, 16(23), 9049 (2000)
  48. Tanev PT, Pinnavaia TJ, Science, 267(5199), 865 (1995)
  49. LaMer VK, J. Am. Ceram. Soc., 4847 (1950)
  50. Ocana M, Rodriguezclemente R, Serna CJ, Adv. Mater., 7, 212 (1995)
  51. Van BA, J. Colloid Interface Sci., 142 (1991)
  52. Messing GL, Zhang SC, Jayanthi GV, J. Am. Ceram. Soc., 76, 2707 (1993)
  53. Brinker CJ, Lu Y, Sellinger A, Fan H, Adv. Mater., 11, 579 (1999)
  54. Lyonnard S, Bartlett JR, Sizgek E, Finnie KS, Zemb T, Woolfrey JL, Langmuir, 18(26), 10386 (2002)
  55. Ward LJ, Schofield WCE, Badyal JPS, Goodwin AJ, Merlin PJ, Langmuir, 19(6), 2110 (2003)
  56. Iskandar F, Mikrajuddin A, Okuyama K, Nano Lett., 1, 231 (2001)
  57. Lu YF, Ganguli R, Drewien CA, Anderson MT, Brinker CJ, Gong WL, Guo YX, Soyez H, Dunn B, Huang MH, Zink JI, Nature, 389(6649), 364 (1997)
  58. Lu Y, Fan H, Stump A, Ward TL, Rieker T, Brinker CJ, Nature, 398, 223 (1999)
  59. Breen ML, Dinsmore AD, Pink RH, Qadri SB, Ratna BR, Langmuir, 17(3), 903 (2001)
  60. Vestal CR, Zhang ZJ, J. Am. Chem. Soc., 124(48), 14312 (2002)
  61. Kolbe G, Ph.D. Thesis, Friedrich-Schiller-University Jena, Germany (1956)
  62. Buchel G, Unger KK, Matsumoto A, Tsutsumi K, Adv. Mater., 10, 1036 (1998)
  63. Yang PD, Zhao DY, Margolese DI, Chmelka BF, Stucky GD, Nature, 396(6707), 152 (1998)
  64. Yang P, Zhao D, Margolese DI, Chmelka BF, Stucky GD, Chem. Mater., 111, 2813 (1999)
  65. Tian B, Yang H, Liu X, Xie S, Yu C, Fan J, Tu B, Zhao D, Chem. Commun., 2178 (2002)
  66. Antonelli DM, Ying JY, Angew. Chem.-Int. Edit., 34, 2014 (1995)
  67. Ciesla U, Schacht S, Stucky GD, Unger KK, Schuth F, Angew. Chem.-Int. Edit., 35, 541 (1996)
  68. Hue QS, Margolese DI, Ciesla U, Feng PY, Gier TE, Sieger P, Leon R, Petroff PM, Schuth F, Stucky GD, Nature, 368(6469), 317 (1994)
  69. Yu C, Fan J, Tian B, Zhao D, Stucky G, Adv. Mater., 14, 1742 (2002)
  70. Yang H, Shi Q, Liu X, Xie S, Jiang D, Zhang F, Yu C, Tu B, Zhao DY, Chem. Commun., 2842 (2002)
  71. Ryoo R, Joo SH, Kruk M, Jaroniec M, Adv. Mater., 13, 677 (2001)
  72. Ryoo R, Joo SH, Jun S, J. Phys. Chem. B, 103(37), 7743 (1999)
  73. Kim M, Yoon S, Sohn K, Kim J, Shin C, Hyeon T, Yu J, Microporous Mesoporous Mater., 63, 1 (2003)
  74. Tian B, Liu X, Yang H, Xie S, Yu C, Tu B, Zhao DY, Adv. Mater., 15, 1370 (2003)
  75. Dong A, Ren N, Tang Y, Wang Y, Zhang Y, Hua W, Gao Z, J. Am. Chem. Soc., 125, 4976 (2004)
  76. Ma Y, Qi L, Ma J, Wu Y, Liu O, Cheng H, Colloids Surf. A: Physicochem. Eng. Asp., 229, 1 (2003)
  77. Burkett SL, Sims SD, Mann S, Chem. Commun., 1367 (1996)
  78. Nassivera T, Eklund AG, Landry CC, J. Chromatogr. A, 973, 97 (2002)
  79. Zhao J, Gao F, Fu Y, Jin W, Yang P, Zhao D, Chem. Commun., 2002, 752 (2004)
  80. Radu D, Lai C, Jeftinija K, Rowe EW, Jeftinija S, Lin V, J. Am. Chem. Soc., ASAP Article (2004)
  81. Radu DR, Lai CY, Wiench JW, Pruski M, Lin VSY, J. Am. Chem. Soc., 126(6), 1640 (2004)