To obtain the optimum synthetic conditions for preparing functionalized glycidyl methacrylate grafted polypropylene (PP-g-GMA) membranes, which selectively adsorb γ-globulins, PP-g-GMA was synthesized by E-beam mutual radiation-induced graft polymerization and subsequent functionalization with diethylamine and sodium sulfate. The amination conversion of the hollow PP-g-GMA membrane increased during the first 12 h of the reaction and then it reached equilibrium; the highest ion exchange capacity (2.6 meq/g) was obtained at a degree of grafting of 223%. The sulfonation conversion of the hollow PP-g-GMA membrane ranged from 18 to 40% after reacting for 6 h; the highest ion exchange capacity (1.7 neq/g) was obtained at a degree of grafting of 205%. From atomic force microscopy (AFM) and scanning electron microscopy (SEM) analyses, the surfaces of the original PP membrane and PP-g-GMA membrane had somewhat-rough topographies, while those of the anion exchange membrane were much smoother because of the pore filling that occurred as the diethylamino groups were introduced onto the PP membrane. In an investigation of the γ-globulin adsorption performance of the hollow PP ion exchange membranes as a function of pH, the maximum γ-globulin uptakes on the cation and anion exchange membranes were obtained at pH 6 and 8, respectively.