화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Journal of the Korean Industrial and Engineering Chemistry, Vol.15, No.7, 693-701, November, 2004
Export Citation
헤파린이 고정화된 신기능 고분자 생체재료
Heparinized Polymeric Biomaterials
배진우, 고동현, 정호진, 김태은, 박기동†
  • 아주대학교 분자과학기술학과, 수원 443-749
Jin Woo Bae, Dong Hyun Go, Ho Jin Chung, Tae Eun Kim, and Ki-Dong Park†
  • Department of Molecular Science and Technology, Ajou University, Suwon 443-749, Korea
E-mail:
초록
헤파린은 글루코사민 계열에 속하는 선형 복합다당류로서 다양한 단백질과의 상호작용을 통해 중요한 생물학적 활성을 나타낸다. 혈액 응고기전에서의 헤파린은 ATIII가 세린 프로테아제를 억제하는 속도를 증가시키는 촉매작용을 함으로써 항응혈제로 널리 이용되어 왔으며, 최근에는 여러 연구자들의 노력에 의해 헤파린과 헤파린결합 단백질과의 상호작용 또한 많이 밝혀져 있는 상태이다. 본 총설에서는 헤파린의 구조 및 헤파린과 단백질과의 상호작용을 통해 나타나는 생리활성에 대해 살펴보고, 헤파린 고정화를 통한 생체적합성이 개선된 신기능 고분자 생체 재료에 대해 알아보았다.
Heparin, a linear polysaccharide belonging to the family of glycosaminoglycans, has numerous important biological activities, associated with its interaction with diverse proteins. Recently, a growing number of biological activities have been discovered to be regulated by the interaction between heparin and heparin-binding proteins. For example, heparin is widely used as an anicoagulant drug based on its ability to accelerate the rate at which antithrombin inhibits serine proteases in the blood coagulation cascade. This review article focuses on aspects of heparin structure, biological activity and various novel biomaterials having improved blood and tissue compatibility by incorporating heparin.
Keywords:heparin;blood compatibility;tissue compatibility;biomaterial
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