The broad objective of this research is to better understand the dissolution processes of drug crystals in the molecular level, especially the interactions between solvent molecules and drug molecules at the interface. For aspirin and alpha-glycine crystals, the (100) face of aspirin and the (010) face of alpha-glycine were used for partial dissolution studies. The etching patterns for both aspirin and alpha-glycine reflect the directionality and strength of the attachment energies projected onto the faces of interest very well, and the predicted etching patterns match observed etching patterns well especially for solvents with weak and moderate solubilizing ability. These results further support our conclusions from earlier publications that surface diffusion, guided by the directional attachment energies, is the primary architect of etching pattern morphology. The solubilizing ability of solvents can significantly affect the surface diffusion time of the involved molecules. In the directions of the dominant attachment energies, the etching patterns in solvents with high solubilizing ability (e.g., pyridine, acetone) become less pronounced than the etching patterns in solvents with low ability (e.g., dichloroethane). Surface adsorption of the solvent also plays an important role in etching pattern formation. In alpha-glycine crystals, acetone may form hydrogen bonds with glycine and introduces certain anisotropy in the relatively deeper etched pits, i.e., oval etching patterns whose basic directionality is, however, still controlled by attachment energy network. Overall, the formation of etching patterns is mainly determined by attachment energies that are important in guiding surface diffusion, and is also affected by solvents with different solubilizing ability and surface adsorption potential.