Epoxidation of propylene to propylene oxide over Ag/TS-1 in the presence of oxygen and hydrogen was carried out in a fixed-bed, quartz flow reactor. The effects of Ag loading, Si/Ti ratio of TS-1 and calcination temperature and calcination method of Ag/TS-1 on the propylene epoxidation were investigated. The results show that Ag loading, the calcination temperature and calcination method of Ag/TS-1 as well as the Si/Ti ratio of TS-1 have a great effect on the catalytic properties. The optimum Ag loading, calcination temperature and calcination method of Ag/TS-1 and Si/Ti ratio of TS-1 are 2 wt%, 450 degreesC in air and 64 respectively. Over 2.0 wt% Ag/TS-1(n(Si)/n(Ti) = 64) catalyst, at a space velocity of 3000 h(-1), 0.92% propylene conversion with 91.21% selectivity to propylene oxide is obtained at 150 degreesC. The deactivation of Ag/TS-1 catalyst is not due to the changes of active species, but because of the coke of the catalyst, which can be easily regenerated by calcination at 450 degreesC in air.