화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Macromolecular Research, Vol.11, No.5, 352-356, October, 2003
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The Effect of Gamma Irradiation on PLGA and Release Behavior of BCNU from PLGA Wafer
Jin Soo Lee, Gang Soo Chae, Gilson Khang†, Moon Suk Kim1, Sun Hang Cho1, and Hai Bang Lee1
  • Department of Advanced Organic Materials Engineering, Chonbuk National University, 664-14, Duckjin Gu, Jeonju 561-756, Korea
  • 1Biomaterials Laboratory, Korea Research Institute of Chemical Technology, P. O. Box 107, Daejeon 305-600, Korea
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The objectives of this study were to investigate the influence of gamma irradiation for sterilization on poly(D,L-lactide-co-glycolide) (PLGA) with different molecular weight and the effect of gamma irradiation on the release behavior of 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU, carmustine) from PLGA wafer with various irradiation doses. The effect of gamma irradiation on PLGA was evaluated by gel permeation chromatography (GPC), differential scanning calorimetry (DSC), and electron paramagnetic resonance (EPR). The weight average molecular weight (Mw) and glass transition temperature (Tg) of PLGA decreased after gamma irradiation. The extent of Mw reduction was dependent on irradiation dose and PLGA molecular weight. Using EPR spectroscopy, we successfully detected gamma irradiation induced free radicals in PLGA. The gamma irradiation increased the release rate of BCNU from PLGA wafer at applied irradiation doses except 2.5 Mrad of irradiation dose in this study.
Keywords:PLGA wafer;gamma irradiation;molecular weight;free radical;BCNU;release profile
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