The design and control of industrial crystallizers continues to be a tremendous challenge. The tendency to move away from base-chemicals towards fine-chemicals will give a new impulse to the utilisation of crystallization technology for the separation and the formulation of particulate products. This paper reviews the most recent developments in the design industrial crystallizers and the development of novel crystallization processes. Furthermore it discusses emerging modeling tools needed for a flexible design and operation of crystallizers and crystallization processes that meet rapid changing product yield and specifications. Finally a new approach towards model-based predictive control of crystallization processes is presented.