High-resolution scanning tunneling microscopy (STM) images at 5 K, simultaneously resolving the molecular adsorbate and the honeycomb structure of the well-defined Ag{111}-p(4 x 4)+Ag1.83O substrate, assign the adsorption site for ethene on the silver oxide surface. Ethene molecules are exclusively adsorbed above a particular subset of Agdelta+ sites in the hexagonal rings of the oxide. Extensive density functional theory (DFT) slab calculations confirm that this is the most stable site, with an adsorption energy of 0.4 eV (39 kJ mol(-1)). Adsorption is accompanied by a large deformation of the hexagonal oxide ring and a significant increase in the C-C bond length. STM image simulations provide qualitative agreement with the experimental images, and the molecular orientation is discussed with the help of simple molecular orbital arguments.