A uranyl Schiff base complex [UO2{OC6H4N=C(H)C6H4O}.H2O] has been immobilized inside the periodic mesopore channels of MCM-41 by the impregnation route. The samples have been characterized by XRD, N-2 adsorption/desorption, TG-DTA, DR UV-vis, Si-29 MAS NMR and FTIR techniques. While the host is found to retain its structural integrity, the surface area and the pore volume decrease considerably as a result of the intrapore confinement of complex molecules. The spectroscopy results indicate that the complex molecules are anchored with the silanol groups of MCM-41 via hydrogen bonding.