화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Macromolecular Research, Vol.11, No.1, 42-46, February, 2003
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In vitro Biodegradability and Surface Properties of Block Copoly(ester-ether)s Consisting of Poly(L-lactide) and Polyether
Chan Woo Lee†, and Yoshiharu Kimura1
  • Department of Innovative Industrial Technology, Hoseo University, Asan-City 336-795, Korea
  • 1Department of Polymer Science and Engineering, Kyoto Institute of Technology, Matsugasaki, Kyoto 606, Japan
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Cell attachment and proliferation on the polymer films of triblock copolymer(ester-ether)s comprising poly(L-lactide)(PLLA) and poly(oxyethylene-co-oxypropylene)(PN) were investigated using 3T3 fibroblasts. It was found that on the tissue culture polystyrene(TCPS) and the PLLA control film the cells could spread well while on the copolymer films the cells showed a rounded morphology without spreading and proliferated weakly. Especially, little cells proliferated on the films of copolymer having a LN composition of 20 wt%. While the water absorption of the copolymer films increased with increasing PN content, the contact angle against water of copolymer films immersed in aqueous medium was almost identical, being slightly lower than that of the PLLA film. These properties were compatible with the results of cell attachment. The in vitro hydrolysis of the films of triblock and multiblock type copolymers was faster with increasing PN content. The increased hydrolyzability, the flexibility and the decreased cell attachment suggested that these copolymers may have high potential as biodegradable materials for medical use.
Keywords:cell attachment;proliferation;fibroblast;flexibility;biodegradable material
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