The reaction of diallyl amine with 1,3-propane sultone led to the synthesis of the zwitterionic monomer 3-(N,N-diallylammonio)propanesulfonate. The sulfobetaine was cyclopolymerized in water in the presence of sodium chloride with t-butylhydroperoxide as an initiator to afford a polysulfobetaine (PSB) in very good yield. PSB, upon treatment with sodium hydroxide, was converted into an anionic polyelectrolyte (APE). Although APE was readily soluble in salt-free water, PSB needed the presence of low-molecular-weight salts (e.g., NaCl, KI, etc., in the range of 0.135-1.04 N) for its dissolution. The solution properties of PSB and APE were investigated with potentiometric and viscometric techniques. The basicity constant of the amine was apparent and followed the modified Henderson-Hasselbalch equation; as the degree of protonation (alpha) of the whole macromolecule increases, the protonation of the amine nitrogens becomes increasingly more difficult. The composition and phase diagram of the aqueous two-phase systems of APE/PSB and poly(ethylene glycol) were also explored.