We studied the kinetic and chemical equilibrium of the transesterification of methyl acetate with n-butanol in a batch stirred-tank reactor with a polymeric acid resin as a catalyst. The aim of this work was to determine whether reactive and extractive distillation is a promising alternative for managing a byproduct from the poly(vinyl alcohol) process. The experiments were performed in concentration and temperature ranges similar to those predicted for operation. The entrainer (o-xylene) was observed to have no influence on the kinetics. Internal and external mass-transfer resistances were found to be negligible under the operating conditions considered. The experimental results were best described (average error of 2%) by a pseudohomogeneous model with a first-order dependency on the reactants. The influence of the temperature was modeled with the Arrhenius equation. The for-ward and reverse kinetic constants were consistent with the chemical equilibrium values.