Biotechnology Letters, Vol.25, No.2, 161-166, 2003
Enzymatic synthesis of hydrophilic undecylenic acid sugar esters and their biodegradability
To enhance water solubility of 10-undecylenic acid, which has anti-fungus, anti-bacterial and anti-virus activity, D-glucose, trehalose and sucrose were regioselectively esterified with vinyl 10-undecylenic acid ester in dimethyl formamide by a commercial protease, Bioprase conc., from Bacillus subtilis. 6-O-(10-Undecylenoyl) D-glucose, 6-O-(10-undecylenoyl) trehalose and 1'-O-(10-undecylenoyl) sucrose were obtained. The influence of structural variation by changing the sugar moiety was analyzed the surface tension and biodegradability.
Keywords:Bacillus subtilis protease;biodegradability;enzymatic synthesis;sugar ester;undecylenic acid