An experimental study of the oxidation of pyridine both in the absence and in the presence of NO has been performed. The experiments were conducted in an isothermal quartz flow reactor at atmospheric pressure in the temperature range 700-1500 K. The influence of temperature, air excess ratio (corresponding to fuel-rich, stoichiometric, and lean conditions), and NO on the concentrations Of CO, CO2, HCN, and NO has been analyzed. The current work contributes to a series of works on the conversion of volatile nitrogen compounds with experimental results related to pyridine. Also, a reaction mechanism based on various literature mechanisms has been used for simulating the experimental results.