Continuous production of lignin-degrading enzymes by Bjerkandera adusta immobilized on polyurethane foam gave maximum activities of 220 U lignin peroxidase ml(-1), 150 U manganese peroxidase ml(-1), 50 U laccase ml(-1) and 6.2 U protease ml(-1) at the retention time of 24 h for 60 days. Protease secretion destabilized the produced lignin peroxidase, manganese peroxidase and laccase.