The relationship between point efficiencies and Murphree tray efficiencies was studied for systems where reactions take place in the liquid within a tray column. For nonreactive systems, several well-known mixing models are available for predicting Murphree tray efficiency from point efficiencies. For reactive systems, the magnitude and nature of the effect of mixing on tray efficiency are different. An analytical representation is developed of the mixed pool and plug flow mixing models for reactive systems with first-order kinetics, and there are different regimes, depending on the reaction kinetics. For each of these regimes, the effect of mixing on tray efficiency differs in magnitude and arises from different mechanisms. The resulting tray efficiencies predicted for reactive systems using the methods may differ by an order of magnitude or more from the values predicted when standard methods for nonreactive trays are applied to reactive trays.