Based on the "triangle method," a shortcut method was developed to establish the possible optimal operating condition of a SMB unit, because the theoretical optimal operating condition was diverted from the actual complete separation region by too many unexpected disturbances. A new CSP was used in the simulated moving bed for the enantioseparation of fluoxetine. Good separation results were obtained. The effects of the difference between m(2) and m(3) on performance parameters were studied. The results show that this method is useful for establishing the operating conditions. It can be concluded that the new CSP is efficient for the enantioseparation of chiral drugs.