Protein Microarrays and Chips

Sang Yup Lee; Seok Jae Lee; Hee-Tae Jung

Journal of Industrial and Engineering Chemistry, Vol.9, No.1, 9-15, January, 2003

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Protein Microarrays and Chips

Sang Yup Lee^†, Seok Jae Lee, and Hee-Tae Jung¹

Metabolic and Biomolecular Engineering National Research Laboratory, Korea Advanced Institute of Science and Technology, Daejeon 305-701, Korea
¹Organic Opto-Electronic Materials Laboratory, Department of Chemical & Biomolecular Engineering, Bioprocess Engineering Research Center, and Center for Ultramicrochemical Process Systems, Korea Advanced Institute of Science and Technology, Daejeon 305-701, Korea

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Recent development of protein microarrays and protein chips is allowing high-throughput analysis of proteins and/or molecules interacting with proteins. Powerful new technologies have currently been reported, which range from synthetic peptide arrays to whole cell protein arrays. Protein chips have been used in various applications for detecting interactions between enzyme-substrate, synthetic molecules-protein and different kinds of protein-protein. Such studies demonstrated that protein chips can be used to examine the functions of thousands of proteins in parallel in a single experiment. This review describes the development of protein microarrays and their potential applications in biological research, medicine and diagnostics.

Keywords:nanotechnology;protein chip;protein microarray;high throughput screening

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[Referenced By]

[Related Articles]

[1] Ramsay G, Nat. Biotechnol., 16, 40 (1998)

[2] Schwarz MA, Hauser PC, Lab Chip, 1, 1 (2001)

[3] Hertzberg RP, Pope AJ, Curr. Opin. Chem. Biol., 4, 445 (2000)

[4] Walter G, Bssow K, Cahill D, Lueking A, Lehrach H, Curr. Opin. Microbiol., 3, 298 (2000)

[5] Pandey A, Mann M, Nature, 405, 837 (2000)

[6] Kodadek T, Chem. Biol., 8, 105 (2001)

[7] Hayhurst A, Georgiou G, Curr. Opin. Chem. Biol., 5, 683 (2001)

[8] Wilson D, Nock S, Curr. Opin. Chem. Biol., 6, 81 (2001)

[9] Mitchell P, Nat. Biotechnol., 20, 225 (2002)

[10] Mirzabekov A, Kolchinsky A, Curr. Opin. Chem. Biol., 6, 70 (2001)

[11] Schweitzer B, Kingsmore SF, Curr. Opin. Biotech., 13, 14 (2002)

[12] Templin MF, Stoll D, Schrenk M, Traub PC, Vhringer CF, Joos TO, Trends Biotechnol., 20, 160 (2002)

[13] Kodadek T, Trends Biotechnol. Sci., 27, 295 (2002)

[14] Reimer U, Reineke U, Schneider-Mergener J, Curr. Opin. Biotechnol., 13, 315 (2002)

[15] MacBeath G, Schreiber SL, Science, 289, 1760 (2000)

[16] Zhu H, Bilgin M, Bangham R, Hall D, Casamayor A, Bertone P, Lan N, Jansen R, Bidlingmaier S, Houfek T, Mitchell T, Miller P, Dean RA, Gerstein M, Snyder M, Science, 293, 2101 (2001)

[17] Afanassiev V, Hanemann V, Wlfl S, Nucl. Acids Res., 28, 66 (2000)

[18] Houseman BT, Huh JH, Kron SJ, Mrksich M, Nat. Biotechnol., 20, 270 (2002)

[19] Lesaicherre ML, Lue RYP, Chen GYJ, Zhu Q, Yao SQ, J. Am. Chem. Soc., 124(30), 8768 (2002)

[20] Yoon SH, Choi JG, Lee SY, J. Microbiol. Biotechnol., 10, 21 (2000)

[21] Mrksich M, Chem. Soc. Rev., 29, 267 (2000)

[22] Lee CS, Kim BG, Biotechnol. Lett., 24(10), 839 (2002)

[23] Piner RD, Zhu J, Xu F, Hong SH, Mirkin CA, Science, 283(5402), 661 (1999)

[24] Lee KB, Park SJ, Mirkin CA, Smith JC, Mrksich M, Science, 295, 1702 (2002)

[25] Cahill DJ, J. Immunol. Methods, 250, 81 (2001)

[26] Haab BB, Dunham MJ, Brown PO, Genome Biol., 2, Research 0004.0001-0004.0013 (2001)

[27] deWildt R, Mundy CR, Gorick BD, Tomlinson IM, Nat. Biotechnol., 18, 989 (2000)

[28] Holt LJ, Enever C, deWildt R, Tomlinson IM, Curr. Opin. Biotechnol., 11, 445 (2000)

[29] Holt LJ, Bssow K, Walter G, Tomlinson IM, Nucl. Acids Res., 28, 72 (2000)

[30] Hanes J, Jermutus L, Weber-Bornhauser S, Bosshard HR, Plckthun A, Proc. Natl. Acad. Sci., 98, 4825 (1998)

[31] Lizardi PM, Huang X, Zhu Z, Bray-Ward P, Thomas DC, Ward DC, Nature Genetics, 19, 225 (1998)

[32] Nallur G, Luo C, Fang L, Cooley S, Dave V, Lambert J, Kukanskis K, Kingsmore S, Lasken R, Schweitzer B, Nucl. Acids Res., 29, 118 (2001)

[33] Schweitzer B, Roberts S, Grimwade B, Shao W, Wang M, Fu Q, Shu Q, Laroche I, Zhou Z, Tchernev VT, Christiansen J, Velleca M, Kingsmore SF, Nat. Biotechnol., 20, 359 (2002)

[34] Hoppe-Seyler F, Butz K, J. Mol. Med., 78, 426 (2000)

[35] Wilson DS, Keefe AD, Szostak JW, Proc. Natl. Acad. Sci., 98, 3750 (2001)

[36] Umezawa Y, Rev. Mol. Biotechnol., 82, 357 (2002)

[37] Oliver SF, Abell C, Curr. Opin. Chem. Biol., 3, 299 (1999)

[38] MacBeath G, Koehler AN, Schreiber SL, J. Am. Chem. Soc., 121(34), 7967 (1999)

[39] Ge H, Nucl. Acids Res., 28, 3 (2000)

[40] Verpoorte E, Electrophoresis, 23, 677 (2002)

[41] Zhu H, Klemic JF, Chang S, Bertone P, Casamayor A, Klemic KG, Smith D, Gerstein M, Reed MA, Snyder M, Nature Genetics, 26, 283 (2000)

[42] Falsey JR, Renil MR, Park S, Li S, Lam KS, Bioconjugate Chem., 12, 346 (2001)

[43] Lesaicherre M, Uttamchandani M, Chen GYJ, Yao SQ, Bioorganic Medicinal Chem. Lett., 12, 2085 (2002)