The features related to nano-alloy anode for Li ion batteries are summarized in this paper mainly based on our recent studies on nano-SnSb. Electrochemical agglomeration, irreversible trapping of inserted ions by host lattice, and unstable solid electrolyte interphase (SEI) film are highlighted. A strategy that pinning nano-alloy particles on the surface of micrometer-sized carbon particles is introduced, in which all components are active for Li storage.