In a previous paper by the same authors, it was shown that for a system with exothermic reversible reaction kinetics, it is possible to cross the reaction equilibrium achieved by a single adiabatic reactor in a system that is overall adiabatic. The work in this paper is a direct continuation of the previous work, but now the cost effects of such a system are considered. Ideas from the attainable region (AR) technique are used to find the optimum process layout and operating conditions for the specified system. The optimum layout consists of interconnections between reactors and internal heat exchangers in which reaction is taking place. It is further shown how the reaction equilibrium can be crossed in a cost-effective manner. For the example studied, the equilibrium conversion of 84% was achieved in a reactor heat interchanger system that has the same cost than a reactor system operating at 48% conversion.