A reduced chemical kinetic model that consists of 19 reactions and 17 species was derived to apply an autoignition model of hydrocarbon fuels. Given the initial fuel-air mixture concentration, temperature, and pressure, the present model was used to predict temperature, pressure, and species concentrations as a function of time. The model was validated with the experimental data where the ignition delays of several hydrocarbon fuels were measured alongside varying equivalence ratios and initial pressures. In particular, changing the rate coefficients of the two reactions in the present model explained the effects of different fuels on ignition delays. As a result, the proposed model is applicable to the autoignition models of various alkane hydrocarbon fuels with different chemical structures, such as n -heptane, iso-octane, n -decane, and an alternative fuel of DME (dimethyl ether), and can simulate high-temperature autoignition of diesel combustion.