The aim of this study is to validate a two-dimensional Eulerian-Lagrangian simulation of heavy metal vaporization in a fluidized bed. Simulation was performed by combining a heavy metal vaporization model and a Lagrangian model developed for bubbling fluidized bed, they are coupled by including the heavy metal transport equation in the gas flow. Experimental data were obtained by fluidizing a mixture of sand and CdCl2-spiked alumina at 1123 K. A fair quantitative agreement was obtained between the predicted and the measured vaporization rate. Moreover, the simulation results address the heavy metal vaporization dynamics at the particle level, and the effect of the particle flow structure on both heavy metal vaporization and vapor distribution in the fluidized bed.