Interaction parameters are presented for four new main groups added to the original UNIFAC table (Hansen, H. K.; Rasmussen, P.; Fredenslund, Aa.; Schiller, M.; Gmehling, J. Ind. Eng. Chem. Res. 1991, 30, 2352). With these new groups, it is possible to describe mixtures with aromatic nitrile groups, epoxy ethers, anhydrides, and aromatic bromo groups. In total 82 new parameter values are reported.