Two desulfurization-regeneration experiments for a spray-dried zinc-based sorbent(ZAC C) were performed at 500 ℃ and 5 atm in a fluidized-bed reactor(ID 0.097 mm) facility. The H2S concentration after each desulfurization run was maintained below 10 ppmv from a simulated coal gas of 1% H2S. The estimated sulfur absorption capacities of ZAC C sorbent were 11.1, 10.9, 11.1, 11.1, 10.9, 10.5 g S/100 g sorbent, and the sorption capacity of sorbent was maintained in spite of six times sorption experiments. The maximum SO2 concentration in regeneration effluent gas agreed with a stoichiometric value of 500 ℃(ca. 14 vol%). In regeneration run, the peak temperature of sorbent bed in the reactor reached up to 750 due to the vigorous exothermicity of regeneration reaction with neat air. While entrainment rate for 70 h continuous run in fluidized-bed reactor is 1.07%, the size and the textural properties of ZAC C sorbent also show a little change. Multi-cycle tests in fluidizedbed show that ZAC C sorbent maintains over 50% of its theoretical sorption capacity during 70 h run and regeneration reaction undergoes smoothly and completely without side reactions such as sulfate formation.