Crystallization and Dissolution Behavior of L(+) Calcium and Zinc Lactate in Ethanol-Water Solvent

Xuejun Cao; Ho-Joon Lee; Hyun Shik Yun; Yoon-Mo Koo

Korean Journal of Chemical Engineering, Vol.19, No.2, 301-304, March, 2002

DOI10.1007/BF02698418 Export Citation

Crystallization and Dissolution Behavior of L(+) Calcium and Zinc Lactate in Ethanol-Water Solvent

Xuejun Cao, Ho-Joon Lee¹, Hyun Shik Yun¹, and Yoon-Mo Koo^{1, †}

State Key Laboratory of Bioreactor Engineering, Department of Biochemical Engineering, East China University of Science and Technology, Shanghai, 200237, China
¹Department of Biological Engineering, Inha University, 253 Yonghyundong,Namku, Incheon 402-751, China

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Crystallization and dissolution behavior of L(+) calcium and zinc lactate in 50% ethanol-water solution was studied. The effects of stirring, standing, ultrasonic wave, and temperature on the crystallization of L(+) calcium and zinc lactate were evaluated. It was found that standing had a positive effect on crystallization of L(+) calcium and zinc lactate, while stirring promoted dissolution of crystallized particles and resulted in high residual concentration in mother liquor. The application of ultrasonic wave did not influence much on crystallization process. L(+) calcium and zinc lactate crystallized easily at 5 ℃; however, complete crystallization took more than 72 hours. These two salts dissolved rapidly and reached equilibrium within 1 hour.

Keywords:L(+) Calcium Lactate;L(+) Zinc Lactate;Crystallization;Dissolution

[References]

Cao X, Lee HJ, Yun HS, Koo YM, Korean J. Chem. Eng., 18(1), 133 (2001)
Chen B, Lu ZT, Huang ZD, J. Huaqiao Univ., 16(3), 318 (1995)
Jin QR, Zhang JM, Xu Q, "Fermentation Technology of Organic Acids," Jin, Q.R., Zhang, J.M. and Xu, Q. eds. Light Industrial Press of China, Beijing (1994)
Keooy PD, "Genital Lubricants Containing Zinc as an Anti-viral Agent," U.S. Patent, 5,599,551 (1997)
Kricheldorf HR, Damrau DO, Macromol. Chem. Phys., 199, 1089 (1998)
Kricheldorf HR, Damrau DO, Macromol. Chem. Phys., 198, 1753 (1997)
Mullin JW, "Crystallization," Butterworth-Heinemann, Ltd., Oxford (1993)
Schwach G, Coudane J, Engel R, Vert M, Polym. Int., 46, 177 (1998)
Shah B, Schmidt N, Nicholas F, "Stable Oral Compositions Containing Zinc and Fluoride Compounds," U.S. Patent, 4,469,674 (1984)
Xue XX, Liu HY, Food Sci., 161(5), 26 (1993)
Yang YH, He B, Li HL, Qi Q, Sun C, Liu D, Henan Sci., 16(2), 218 (1998)
Zhang SP, Zhu J, Wang XC, Res. Develop. Food, 3, 28 (1994)

[Referenced By]

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[1] Cao X, Lee HJ, Yun HS, Koo YM, Korean J. Chem. Eng., 18(1), 133 (2001)

[2] Chen B, Lu ZT, Huang ZD, J. Huaqiao Univ., 16(3), 318 (1995)

[3] Jin QR, Zhang JM, Xu Q, "Fermentation Technology of Organic Acids," Jin, Q.R., Zhang, J.M. and Xu, Q. eds. Light Industrial Press of China, Beijing (1994)

[4] Keooy PD, "Genital Lubricants Containing Zinc as an Anti-viral Agent," U.S. Patent, 5,599,551 (1997)

[5] Kricheldorf HR, Damrau DO, Macromol. Chem. Phys., 199, 1089 (1998)

[6] Kricheldorf HR, Damrau DO, Macromol. Chem. Phys., 198, 1753 (1997)

[7] Mullin JW, "Crystallization," Butterworth-Heinemann, Ltd., Oxford (1993)

[8] Schwach G, Coudane J, Engel R, Vert M, Polym. Int., 46, 177 (1998)

[9] Shah B, Schmidt N, Nicholas F, "Stable Oral Compositions Containing Zinc and Fluoride Compounds," U.S. Patent, 4,469,674 (1984)

[10] Xue XX, Liu HY, Food Sci., 161(5), 26 (1993)

[11] Yang YH, He B, Li HL, Qi Q, Sun C, Liu D, Henan Sci., 16(2), 218 (1998)

[12] Zhang SP, Zhu J, Wang XC, Res. Develop. Food, 3, 28 (1994)