Biosolids (BS) from food processing plants are usually put on land or in landfills. They contain nutrients and could be fed to animals, but low digestibility is a limitation. Lab tests were conducted to evaluate treatments that might increase digestibility of BS. Biosolids were extruded or treated with chemicals and filtered; residues were incubated with proteases. Dry matter disappearance (DMD), measured as weight loss of treated material following filtration, was considered an indicator of digestibility. The DMD of extruded BS (31-35%) was greater than oven-dried BS (20-27%). Increasing extruder temperature or speed increased DMD by small but significant amounts. Chemical treatment of BS with HCL, AP and NaOH significantly increased DMD to 60-70%; increases were larger than responses to extrusion. Responses were attained differently; on one hand, for HCL and AP treatments, about 50% of the increase in DMD was due to solubilization and 50% due to degradation. On the other hand, NaOH acted almost completely by solubilization Increased DMD infers that BS should have increased digestibility when fed to animals, but feeding studies are needed for substantiation.