Pt/Nb2O5 catalysts were prepared with different loadings of Pt and characterized by TPR, DRS, H-2 and CO chemisorption and H-2/O-2 titration. Higher metal content catalysts presented an increasing SMSI effect related to a lower adsorption capacity. The Pt blocking by NbOx species causes the formation of new interfacial active sites. After a high temperature reduction, the catalysts were highly selective towards dehydrogenation products and total inactive for hydrogenolysis in the case of n-heptane conversion.