The reaction of ethane-oxygen mixtures with ozone as a sensitizer in the feed-gas was quantitatively studied at near atmospheric pressure in a dual-flow system. Ozone was generated by silent discharge. The influence of reaction temperature, oxygen concentration in the feed-gas, residence time in the reactor, and ozone concentration in oxygen on the reaction were investigated. Ethanol selectivities (based on carbon) between 3.95 and 21.8% and methanol selectivities between 17.1 and 41.0% with the combined formaldehyde-acetaldehyde-methanol-ethanol (FAME) selectivities between 36.7 and 95.7% were observed for ethane conversion equal to or less than 6.1%. The FAME selectivity was found to be over 90% when the ethane conversion was below 3.5%.