This article considers the issue of designing robust controllers for single-input/single-output nonlinear chemical processes whose uncertainties satisfy the so-called generalized matching condition. The nominal system (mathematical model) is assumed to be input-output linearizable and the only assumption on uncertainties is that they are bounded. A design methodology of combining the techniques of the differential geometric feedback linearization, the sliding mode control strategy and the adaptive state feedback is presented. Based on the nominal system and the related bounds of uncertainties, a hybrid nonlinear controller, which is more practicable and easily implemented than many other existing ones in the literature, is proposed. A Lyapunov-based approach is utilized to guarantee the robust stability and behavior of the closed-loop system. For demonstrating the effectiveness and applicability of the proposed scheme, we applied it to the control of a continuously stirred tank reactor (CSTR) in the presence of uncertainties including unmodeled side reaction, measuring error, and/or extra unmeasured disturbances. The potential use of a sliding observer along with the proposed scheme is also investigated in this work. Extensive simulation results reveal that the proposed scheme appears to be a practical and promising approach to the robust control of nonlinear uncertain chemical processes,