In order to describe how a conduction calorimeter works, a novel model, namely the interfacial model of a conduction calorimeter, has been proposed in this paper. Based on the model, a corresponding analog thermo-analytical curve equation has also been established. For verification of its validity, thermo-analytical curves of alkaline hydrolysis of ethyl propionate and ethyl acetate have been measured at 25 degrees C, respectively. The data calculated by this model are in reasonable agreement with those read from the thermo-analytical curves.