A dynamic model for the liquid-phase methanol synthesis with the Langmuir-Hinshelwood kinetic formulation is presented for a well-mixed slurry reactor. Responses to a step-change in the reactor feed composition were studied in a temperature range of 200-240 degreesC and total pressures between 34 and 41 bar. A commercial Cu/ZnO/Al2O3 and squalane were used as a catalyst and inert liquid phase, respectively. All transport, kinetic, and adsorption parameters, excepting the equilibrium adsorption constants for water and methanol, were evaluated in separate experiments. The two parameters were obtained by fitting the model predictions to the experimental responses and were found to obey the van't Hoff relation. A good agreement between experimental and predicted results found in a rather wide range of operating conditions validates the Langmuir-Hinshelwood kinetic formulation as an appropriate tool for describing the processes on catalyst surface.