The design of an industrial gas adsorption column for the removal of hexafluoropropylene (HFP) from wet air is reported. The column uses activated carbon and operates under the strongly fluctuating concentration conditions of an industrial plant. An important aspect of this study was to investigate the influence of water vapor in the feed on the performance of the adsorption column. During regeneration of the carbon, unforeseen reactions of HFP on carbon occurred at elevated temperatures, imposing constraints on the regeneration conditions. A two-dimensional mathematical model for the adsorber worked, well. Design calculations were performed on the basis of the experimental results. The Dubinin-Radushkevich model described the adsorption equilibrium substantially better than did the Langmuir model. It is demonstrated that a correct adsorption isotherm is more crucial than particle kinetics in designing the adsorption column. Decoupling hydrodynamics from the rate processes by filling the bed with fines of an inert material worked well, enabling the breakthrough experiments to be downscaled.