Propagation of circular NAD(P)H autofluorescence and proton waves (target patterns) was detected in individual living human neutrophils using high-speed fluorescence microscopy. Waves were initiated at the point where a cell attached to the substrate followed by propagation to the cell's periphery. The time-dependence of wave propagation and critical radius are in reasonable agreement with theoretical expectations. We suggest that physical-chemical self-organization of metabolism is a fundamental aspect of cell function.