The effect of increasing the number of CFSTRs either in a growth stage or production stage of a two step fermentation of a recombinant bacterium with an environmentally regulated gene has been investigated. The performance of the multiple CFSTR fermentation at its optimum design is compared to an optimum two stage fermentation. The results show that increasing the number of CFSTRs in the growth stage does not have any effect on the performance of the system, while increasing the number of CFSTRs in the production stage increases the productivity. The increase in the productivity, however, is small compared to the increase in the productivity that occurs with primary products, as reported in the literature. It is also shown that the results can be extended to other recombinant bacteria fermentations.