Journal of the American Chemical Society, Vol.119, No.51, 12465-12470, 1997
Glycolipids from sponges. 6. Plakoside A and B, two unique prenylated glycosphingolipids with immunosuppressive activity from the marine sponge Plakortis simplex
Plakoside A (la) and B (29), two unique glycosphingolipids belonging to a new class of prenylated glycolipid, have been isolated from the marine sponge Plakortis simplex, and their structures have been determined by spectroscopic and chemical means. Plakosides are strongly immunosuppressive on activated T cells and proved to be useful natural models for an improved comprehension of the structural requirements for immunomodulating activity of glycosphingolipids.