Journal of the American Chemical Society, Vol.120, No.24, 5921-5942, 1998
General strategies toward the syntheses of macrolide antibiotics. The total syntheses of 6-deoxyerythronolide B and oleandolide
The asymmetric syntheses of 6-deoxyerythronolide B (1) and oleandolide (2) have been achieved, each in 18 linear steps. These syntheses demonstrate the utility of chiral beta-keto imide building block 3 as a versatile building block for the aldol-based assemblage of polypropionate-derived natural products.