Journal of the American Chemical Society, Vol.121, No.24, 5640-5644, 1999
Titanocene-catalyzed asymmetric ketone hydrosilylation: The effect of catalyst activation protocol and additives on the reaction rate and enantioselectivity
The efficient asymmetric hydrosilylation of ketones with a chiral titanocene catalyst has been realized. In this procedure, (R,R)-ethylenebis(tetrahydroindenyl) titanium difluoride (1) was used as the precatalyst, and alcohol additives were employed. Aromatic and alpha,beta-unsaturated ketones were reduced to the corresponding alcohols with a high level of enantioselectivity.