Desorption experiments are conducted for several blowing agents in polyurethane at room temperature and with various blowing agent pressures. The diffusivity and solubility data for blowing agents are compared with the corresponding values for chlorofluorocarbon 11 (CFC 11). In addition, the solubility and diffusivity for these blowing agents in polyurethane are explained in terms of the solubility parameter and van der Waals volume, respectively. The calculated permeabilities based on the measured diffusivities and solubilities indicate that among the nine blowing agents investigated in this study, eight blowing agents can be possible candidates for substitutes of CFC 11 in polyurethane foams.