The ternary reactive blend of Nylon 6 matrix with dispersed poly(styrene-co-maleic anhydride) and maleated SEES or EPR represents a toughened system with enhanced strength and, at least, the retained stiffness of the matrix. In the present work, the influence of changed reactivity of dispersed phases, including the application of one or both nonreactive components, on the phase structure and related mechanical behavior is studied. Lowering of the reactivity of the elastomer caused a decrease of blend properties, whereas suitable dilution of SMA by PS brought better properties in comparison with a fully reactive system. With the nonreactive N6/PS/SEBS blend, the formation of blended bicontinuous inclusions causes worsening of toughness. This documents the importance of separate dispersion of both phases for good mechanical behavior in the system studied, which is shown to be assured by application of at least one reactive component.