Aqueous solutions containing heavy metals can be successfully treated by a combination Of biosorption and flotation, in order to remove (or recover) the contained metals. Nonliving biomass of yeast Saccharomyces, which is a solid industrial by-product, was found to be a suitable biosorbent of metal ions (zinc, copper, and nickel). It was found also possible to reuse it after the appropriate desorption treatment. Electrokinetic behavior of biomass as well as elution and multiple-cycles operation were investigated. The dispersed-air flotation technique, which was selected for generation of bubbles, was subsequently examined for solid/liquid separation, In order to hart est the metals-loaded biomass downstream. The main parameters affecting the flotation process were studied, Such as the solution pH, the concentration of notation collector (surfactant), the preliminary biomass modification, and the biomass concentration: The biosorptive flotation method was found promising for remediation applications of wastewaters containing toxic metals.