Simulation of the MTG process carried out in a fluidized bed reactor-regenerator system with catalyst circulation is studied by using the kinetic results obtained in an experimental unit. Data considered covered a wide range of operating conditions including temperature, space time and average residence times in both reactor and regenerator. This simulation is based on the use of adequate kinetic equations for the main MTG reaction, for the catalyst deactivation and for catalyst regeneration. In addition, a third stage in the process allowing for coke equilibration, prior to its combustion, is also included. Catalyst loss due to attrition has also been taken into account. An objective function based on relative production rate is optimized by changing systematically the process parameters such as temperature, space time and catalyst activity. Results are also validated in the experimental unit and demonstrate the simplicity of the reactor-regenerator system with catalyst circulation and the versatility of this configuration for carrying out the MTG process.