The second part of this paper applies the techniques developed in the first part to four literature examples, featuring among them multiple mass separating agents (MSAs), multiple components being transferred, regeneration of one of the MSAs, and reactive mass exchange with non-linear equilibrium relationships. In all but the simplest example, the designs developed using these techniques had total annual costs (TACs) which were significantly less than those previously obtained when optimizing the problems using MINLP and state-space methods. In all cases the targets obtained by supertargeting before design were closely approached in design, indicating that these targets may meaningfully be used to screen alternative design options.