High initial conversions for the cyclododecatriene (CDT) hydrogenation in a slurry reactor at 433 K and 1.2 MPa were obtained from a supercritical (sc) CO2-cleaned 0.5% Pd/Al2O3 catalyst. A recovered intermediate selectivity was achieved by the sc CO2-cleaned catalyst at the higher CDT conversion values, suggesting an effective cleaning of Pd; sites and a possible reconstruction of the residual coke layers onto the surface caused by the solvent nature of sc CO2. SEM pictures show that the cleanup of the used catalyst with sc CO2 removes most of the coke and oily materials from the surface. Pd SEM X-ray microanalysis evidenced a decrease of the Pd dispersion on the surface of the used-activated catalyst. Coke was also characterized using elemental analysis and TCA in air, indicating that about 80 wt % of the deactivating materials were efficiently removed from the surface by sc CO2. The formation of the oligomerized and stabilized residual coke (remaining 20%) should be presumably avoided if the catalytic hydrogenation had taken place at sc tin situ) conditions where oligomerization times are minimized. The SCF conditions are then highly challenging at the catalytic hydrogenation of polyunsaturated hydrocarbons.