Biotechnology and Bioengineering, Vol.71, No.1, 71-77, 2000
The preparation of amino-substituted biaryl libraries: The application of solid-supported reagents to streamline solution-phase synthesis
A small library of isomeric benzylamino biaryls was generated in a semi-automated fashion using a solution-phase strategy employing a solid-supported, readily filterable base to facilitate electrophilic substitution followed in sequence by a metal-catalyzed cross-coupling reaction. (C) 2000 John Wiley & Sons, Inc.