A series of four molecular dynamics computer simulations totaling more than 40 ns in length have been carried out on hydrated bilayer systems to study the interaction between a diacylphospholipid, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC), and an oligo(ethylene oxide) alkyl ether detergent, C12E4. Simulations of pure lipid bilayers, pure detergent bilayers, and a mixed system in a 5:1 lipid-to-detergent ratio, show good agreement with experimental measurements. The simulations confirm experimental observations of the membrane's ability to significantly alter the conformations of the solute detergent molecules and offer an explanation of some seemingly contradictory experimental results. In addition to providing a molecular level explanation of the changes in solute structure, the present simulations demonstrate the importance of environment on solutes incorporated into membranes and show that molecular dynamics simulations is a tool with great potential for the study of membrane-polymer interactions.