Different expressions have been determined experimentally for reactivation kinetics of a catalyst based on a HZSM-5 zeolite, which is used in the transformation of methanol into hydrocarbons in a fixed bed reactor operating under reaction-re generation cycles. When operation is carried out in isothermal regime, the design of the process is carried out by using a relationship of recovered activity to coke combustion time. This relationship is used in the design together with the kinetic models of the main reaction and of the deactivation by coke, in which the effect of attenuation by water in the reaction medium is taken into account. In order to design the cyclic operation in adiabatic regime. a relationship of recovered activity to coke content is used. This reactivation kinetics is different to the activity-coke content relationship corresponding to the reaction stage.